RELEVANT PUBLICATIONS

Chen RJ, Nabila A, Phalke S, Castro DF, Toth JG, Bergin P, Bastiaans J, Stuhlmann H, Pernis AB, Toth M. Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture. Iscience. 2022 Dec 22;25(12):105595.

Toth M. Epigenetic neuropharmacology: drugs affecting the epigenome in the brain. Annual Review of Pharmacology and Toxicology. 2021 Jan 6;61:181-201. doi.org/10.1146/annurev-pharmtox-030220-022920

Taki F, Lopez K, Zupan B, Bergin P, Docampo MD, Alves-Bezerra M, Toth JG, Chen Q, Argyropoulos KV, Barboza L, Pickup E, Fancher N, Hiller A, Gross S, Cohen DE, van den Brink MRM, Toth M. Maternal programming of social dominance via milk cytokines. iScience . 2020 Aug 21;23(8):101357. doi: 10.1016/j.isci.2020.101357. Epub 2020 Jul 10.

Odell SC, Taki F, Klein SL, Chen RJ, Levine OB, Skelly MJ, Nabila A, Brindley E, Gal Toth J, Dündar F, Sheridan CK, Fetcho RN, Alonso A, Liston C, Landau DA, Pleil KE, Toth M. Epigenomically bistable regions across neuron-specific genes govern neuron eligibility to a coding ensemble in the hippocampus. Cell Rep . 2020 Jun 23;31(12):107789. doi: 10.1016/j.celrep.2020.107789.

Toth M. The other side of the coin: hypersociability. Genes Brain Behav. 2018 Aug 13:e12512. doi: 10.1111/gbb.12512.

Zupan B, Liu B, Taki F, Toth JG, and Toth M. Maternal brain TNF-a programs innate fear in the offspring. Curr Biol. 2017 Dec 18;27(24):3859-3863.e3. doi: 10.1016/j.cub.2017.10.071. 

Mitchell E, Klein SL, Argyropoulos KV, Sharma A, Chan RB, Toth JG, Barboza L, Bavley C, Bortolozzi A, Chen Q, Liu B, Ingenito J, Mark W, Dudakov J, Gross S, Di Paolo G, Artigas F, van den Brink M, and Toth M. Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms. Nat Commun. 2016 May 13;7:11492. doi: 10.1038/ncomms11492.

Sharma A, Klein SS, Barboza L, Lohdi N, and Toth M. Principles Governing DNA Methylation during Neuronal Lineage and Subtype Specification. The Journal of Neuroscience, February 3, 2016 36(5):1711-1722

Zupan B, Sharma A, Frazier A, Klein S, and Toth M. Programming social behavior by the maternal fragile X protein. Genes Brain Behav. 2016 Jul;15(6):578-87. doi: 10.1111/gbb.12298. Epub 2016 Jun 10.. 

Toth M. Mechanisms of Non-Genetic Inheritance and Psychiatric Disorders. Neuropsychopharmacology. 2014 Jun 3. doi: 10.1038/npp.2014.127. 

Abbott GW1, Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, and Berry GT. KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Sci Signal. 2014 Mar 4;7(315):ra22. doi: 10.1126/scisignal.2005025. 

Liu B, Zupan B, Laird E, Klein S, Gleason G, Bozinoski M, Gal Toth J and Toth M. Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory. Nat Neurosci. 2014 Jan;17(1):97-105. 

Li Q, Bian S, Liu B, Hong J, Toth M and Sun T. Establishing brain functional laterality in adult mice through unilateral gene manipulation in the embryonic cortex. Cell Res. 2013 Sep;23(9):1147-9. 

Oh JE, Chambwe N, Klein S, Gal J, Andrews S, Gleason G, Shaknovich R, Melnick A, Campagne F, and Toth M. Differential gene body methylation and reduced expression of cell adhesion and neurotransmitter receptor genes in adverse maternal environment. Translational psychiatry 2013 Jan 22;3:e218.

Hartrampf S, Dudakov JA, Johnson LK, Smith OM, Tsai J, Singer NV, West ML, Hanash A, Albert MH, Liu BF, Toth M, and van den Brink MRM. The Central Nervous System is a Target of Acute Graft-Versus-Host Disease. Blood, 2013 Mar 7;121(10):1906-10.

Bortolozzi A, Castan J, Semakova A, Santana N, Alvarado G, Cortes R, Ferres-Coy A, Fernandez G, Carmona MC, Toth M, Perales JC, Montefeltro A and Artigas F. Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects. Mol. Psychiatry. 2011. advance online publication 2 August 2011.

Gleason G, Liu B, Bruening S, Zupan B, Auerbach A, Mark W, Oh JE, Gal-Toth J, Lee F and Toth M. The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7592-7.

Zupan B and Toth M. Wild type male offspring of fmr-1+/- mothers exhibit characteristics of the fragile x phenotype.  Neuropsychopharmacology. 2008 Oct;33(11):2667-75.

Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, Sealfon SC, Hen R, Gingrich JA. Cortical 5-HT2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice. Science, 313(5786):536-40, 2006.

Kushnir-Sukhov NM, Gilfillan AM, Coleman JW, Brown JM, Bruening S, Toth M, and Metcalfe DD. 5-hydroxytryptamine induces mast cell adhesion and migration. J. Immunology, 177:6422-6432, 2006.

Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, Hempstead BL, and Lee FS. Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-related Behavior. Science, 314:140-3, 2006.

Baile  SJ and Toth M. Variability in the benzodiazepine response of serotonin 5-HT1A receptor null mice displaying anxiety-like phenotype: evidence for genetic modifiers in the 5-HT mediated regulation of GABAA receptors. J. Neuroscience. 24:6343-6351, 2004. PMID: 15254090.

Liu W, Seto J, Donovan G, and Toth M. Jerky, a protein deficient in a mouse epilepsy model, is associated with translationally inactive mRNA in neurons. J. Neuroscience 22: 176-182, 2002. PMID: 11756500.

Sibille E, Pavlides C, Benke D, and Toth M. Genetic inactivation of the 5-HT1A receptor in mice results in down-regulation of major GABAA receptor subunits, reduction of GABAA receptor binding, and benzodiazepine-resistant anxiety. J. Neuroscience 20, 2758-2765, 2000. PMID: 10751426.

Sarnyai Z, Sibille E, Pavlides C, McEwen B, and Toth M. Functional abnormalities in the hippocampus and impaired hippocampal-dependent learning in mice lacking the 5HT1A receptors. Proc. Natl. Acad. Sci. USA. 97, 14731-14736, 2000. PMID: 11121072.

Parks C, Sibille E, Robinson T, Shenk T, and Toth M. Anxiety of mice lacking the serotonin1A receptor. Proc. Natl. Acad. Sci. USA. 95,10734-10739, 1998. PMID: 9724773.

Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, Adams JD, Karoum K, Gal J, and Shih JC. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nature Genetics 17, 206-210, 1997. PMID: 9326944.

Toth M, Grimsby J, Buzsaki G, Donovan, GP. Epileptic seizures caused by inactivation of a novel gene, jerky, related to centromere binding protein–B in transgenic mice. Nature Genetics 11, 71-75, 1995. PMID: 7550318.

Kochanek S, Toth M, Dehmel A, Rehr O, and Doerfler W. Interindividual concordance of methylation profiles in human genes for tumor necrosis factors alpha and beta. Proc. Natl. Acad. Sci. USA. 87: 8830-8834, 1990. PMID: 2247453.

Toth M, Lichtenberg U, and Doerfler W. Genomic sequencing reveals a 5-methyldeoxycytosine-free domain in active promoters and the spreading of preimposed methylation patterns. Proc. Natl. Acad. Sci. USA. 86: 3728-3732, 1989. PMID: 2524831.